compare and contrast Major Depressive Disorder, Persistent Depressive Disorder (Dysthymia), and Vascular Depression

Please respond to each of the following questions with at least a one paragraph response.

1) Define a mental disorder.  Then compare and contrast Major Depressive Disorder, Persistent Depressive Disorder (Dysthymia), and Vascular Depression.

2) What are some of the findings from neuroimaging techniques on Depression?  What functional differences have been identified?

3) How do anti-depressants help treat Depression/Depressive-like symptoms?

4) How are animal models used to identify antidepressant drugs (Box 13.1)?

5) What is the Monoamine Hypothesis of Depression?

6) Compare and contrast MAO inhibitors, irreversible MOA inhibitors, reversible inhibitors, selective MAO inhibitors, reversible inhibitors of MAO-A (RIMA).

7) Compare and contrast tricyclic antidepressant drugs, selective serotonin reuptake inhbitiors (SSRIs), serotonin-norepinephrine reuptake inhibitors (SNRIs), and atypical antidepressant drugs/multimodal antidepressant drugs, and treatment resistant depression.

8) Explain the “cheese reaction,” serotonin syndrome, serotonin discontinuation syndrome, and emotional blunting.

9) Compare and contrast Bipolar Disorder, Mania, Euthymia, Type I Biploar Disorder, and Type II Bipolar Disorder.

10) Compare and contrast the neurotransmitters and neurobiology of Depression and Bipolar Disorder.

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